therapeutically active organic producers and its anvendning

摘要

Therapeutically active organic compound exhibiting at least one group comprising a structure -S min -S sec -R, wherein the group -S sec -R is defined by R being an organic group comprised in a physiologically acceptable compound H-S sec -R obtainable by the splitting of the disulfide bridge -S min -S sec - in said structure, in which compound H-S sec -R the sulfur atom S sec is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H-S sec -R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S sec bound to R, so as to be mainly excluded from reaction involving thiol disulfide exchange; S min being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure -S min -S sec -R, consisting of a residue of a therapeutically active organic base compound of non-poly-peptide structure bound to S min . The invention also relates to a method of modifying a therapeutically active organic compound of non-polypeptide structure by introducing a structure -S min -S sec -R according to above; a method of treating diseases by administration of a compound according to the invention and also to a pharmaceutical composition containing at least one compound according to the invention.