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14-DE(HYDROXYMETHYL)-MYCAMINOSYL TYLONOLIDE DERIVATIVE AND ITS PRODUCTION
14-DE(HYDROXYMETHYL)-MYCAMINOSYL TYLONOLIDE DERIVATIVE AND ITS PRODUCTION
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机译:14-DE(羟甲基)-麦氨酰酪氨酰衍生物及其生产
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摘要
NEW MATERIAL:The compound of formula I [R is H or OH] and its salt. EXAMPLE:14-De(hydroxymethyl)-O-mycaminosyl tylonolide. USE:Antibacterial agent for Gram-positive bacteria having extremely strong antibacterial activity compared with known tylosin. It is effective even to resistant bacteria and Gramnegative bacteria, and is useful also as a remedy for infectious diseases of animals and as a feed additive. It can be administered by injection as well as by oral administration. PREPARATION:The compound of formula II [R1 is H or -OR2 (R2 is OH-protecting group); R3 and R4 are lower alkyl or together form lower alkylene] is deformylated, and the product is subjected to the removal of the OH-protecting group and of the acetal group.
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机译:新材料:式I的化合物[R为H或OH]及其盐。实施例:14-De(羟甲基)-O-mycaminosyl tylonolide。用途:与已知的泰乐菌素相比,革兰氏阳性细菌的抗菌活性极强。甚至对抗性细菌和革兰氏阴性菌也有效,并且还可以用作动物传染病的治疗剂和饲料添加剂。既可以注射也可以口服。制备:式II化合物[R1为H或-OR2(R2为OH-保护基); R 3和R 4是低级烷基或一起形成低级亚烷基]被去甲酰基化,并使产物脱去OH-保护基和缩醛基。
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