REMEDY FOR CARDIOPATHY CONTAINING NEW DITERPENIC ALKALOID AND DITERPENIC ALKALOIDS AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A diterpenic alkaloid expressed by formula I (As is formula II). USE:A remedy for cardiopathy useful for treating cardiac infarction, angina pectoris and arrhythmia. PREPARATION:Aconitum contortum is extracted with at least one mixed solvent selected from water, methanol, ethanol, acetone, ethyl acetate, etc., to provide an extract solution, which is then concentrated and subsequently dissolved in water. The liquid quality of the resultant solution is regulated to pH 3 with a 2% hydrochloric acid and the resultant solution is defatted with ether. The liquid quality of the aqueous layer after the defatting is then regulated to pH 8 with aqueous ammonia and the regulated aqueous layer is subsequently extracted with chloroform. The obtained chloroform layer is then subjected to column chromatography using a solvent such as water, aqueous ammonia and diethylamine several times to distill away the solvent from the eluted fraction, etc., Thereby, the compound expressed by formula I is obtained.