AMINO GLYCOSIDE COMPOSITION FOR SUBSTANTIALLY DECREASING NEPHROTOXICITY INDUCED BY AMINO GLYCOSIDE

摘要

PURPOSE: To obtain an aminoglycoside composition capable of reducing nephrotoxicity induced by an aminoglycoside useful as an antibiotic, an antimicrobial agent, etc. CONSTITUTION: This aminoglycoside composition comprises a compound of formula I to formula II (R1 and R2 are each a 2-6C alkyl, cyclohexyl, alkoxyalkyl or hydroxyalkyl; A is a =4C hydrocarbon group substitutable with methyl; at least one of R3 and R4 is a group of formula III and the other is H or a =6C aliphatic hydrocarbon group which is interrupted with an oxygen atom having = two carbon chains or is substitutable with one oxygen atom or two hydroxyl groups; R6 is a 1-3C alkyl; (n) is an integer of 2-5), preferably one or more compounds selected from 1,3-di-n-butyl-7-(2-oxopropyl)xanthine and 7-(3-oxobutyl)-1,3-di-n-butylxanthine and is capable of reducing nephrotoxicity of an aminoglycoside such as gentamicin, amikacin, kanamycin and neomycin, especially neomycin.