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The inclusion complex which is formed N-etokishi carbonyl - 3 - the morpholino - making use of sydnone imine or, the cyclodextrin derivative of that salt, those manufacturing methods and the medicine constituent null which contains the said complex
The inclusion complex which is formed N-etokishi carbonyl - 3 - the morpholino - making use of sydnone imine or, the cyclodextrin derivative of that salt, those manufacturing methods and the medicine constituent null which contains the said complex
Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pectoris. It also has antiarrhythmic, fibrinolytic, platelet aggregation inhibitory and hypotensive activity. Pref. (III) are selected from beta-cyclodextrin (BCD), gamma-cyclodextrin, heptakis-2,6,O-dimethyl -beta-cyclodextrin and hydroxypropyl- beta-cyclodextrin.
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