Analogifremgangsmaade for the preparation of pGRF pGRF analogs or peptides, pharmaceutically acceptable addition salts thereof as well as intermediate for use in the method

摘要

PGRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr- Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys- Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly- Glu-R34-Asn-Gln-Glu-R38-Gly-R40-R41-R wherein R is OH or NH2, R34 is Ser or Ala, R38 is Arg or Ser, R40 is Ala or Arg and R41 is Arg, Arg-Ala, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R41. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically.