2-thioxo-5-PYRIMIDINCARBOXAMIDER, pharmaceutical composition containing them for inducing regression of leukemia and inhibition of the growth of tumors and methods of their production

摘要

Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula: IMAGE wherein: R is hydrogen, 2- or 3-halo, 4-fluoro, 2-methyl, 2- or 4-alkoxy, or 2- or 4-trifluoromethyl, and R1 is hydrogen; or R is 2-fluoro and R1 is 4-fluoro; or R is 2-methoxy and R1 is 5-methyl; and R2 and R3 are hydrogen atoms or carbohydrate residues; and, with the exception of the compound wherein R is 4-methoxy and R1 is hydrogen, the pharmacologically acceptable acid-addition salts thereof.