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PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS COMPRISING 1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES AS ACTIVE INGREDIENT AND FOR PRODUCING THE ACTIVE INGREDIENTS
PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS COMPRISING 1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES AS ACTIVE INGREDIENT AND FOR PRODUCING THE ACTIVE INGREDIENTS
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机译:制备包含1H-咪唑和1H-1,2,4-三唑作为活性成分的药物成分并生产活性成分的方法
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摘要
Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4 -yl] methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula CHEM wherein Q is N or CH; R is hydrogen, C1-6alkyl or arylC1-6alkyl; and R1 is hydrogen, C1-6alkyl or arylC1-6alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
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