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PROCESS FOR PRODUCING 3,5-DIAMINO-6-(4-AMINOCHLOROPHENYL)-1,2,4-TRIAZINE DERIVATIVES ACTING ON CENTRAL NERVOUS SYSTEM, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS
PROCESS FOR PRODUCING 3,5-DIAMINO-6-(4-AMINOCHLOROPHENYL)-1,2,4-TRIAZINE DERIVATIVES ACTING ON CENTRAL NERVOUS SYSTEM, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS
The invention provides compounds of formula (I) CHEM wherein at least one of R1, R2 and R3 is chloro and the others are selected from hydrogen and chloro; and R4 and R5 are the same or different and are each alkyl or hydrogen. The compounds may be used for the treatment or prophylaxis of a neurodegenerative of other neurological disorder of the CNS, the aetiology of which includes excessive release of the neurotransmitter glutamate.
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机译:本发明提供了式(I)的化合物,其中R 1,R 2和R 3中的至少一个是氯,并且其他选自氢和氯; R 4和R 5相同或不同,分别为烷基或氢。该化合物可用于治疗或预防中枢神经系统其他神经系统疾病的神经变性,其病因包括神经递质谷氨酸的过度释放。
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