BASICALLY SUBSTITUTED DITERTIARY UREAS IN THE SERIES OF CONDENSED TRICYCLIC 1,4-DIAZEPIN-5-ONES,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Condensed diazepinones of the general formula I IMAGE in which IMAGE represents one of the divalent radicals IMAGE and X1, X2, A, R1 to R10 and Z have the following meanings: X1 and X2 represent a = CH-group or, if IMAGE assumes the meanings of the abovementioned divalent radicals (S), (U) or (W), both or only X1 or only X2 can also represent a nitrogen atom; A is an alkylene radical having two to seven carbon atoms; which can also be interrupted by an oxygen or sulphur atom or by the methylimino or ethylimino group; Z is a single bond, an oxygen or sulphur atom, the methylene or 1,2-ethylene group; R1 is a lower alkyl radical or the benzyl group; R2 is an alkyl radical having 1 to 7 carbon atoms, which can optionally be further substituted by a hydroxyl group on its 2nd to 7th carbon atom, a cycloalkyl or a cycloalkylmethyl radical, where the cycloalkyl ring can optionally be further substituted by a hydroxyl group; R1 and R2, however, together with the nitrogen atom lying in between, can also form a 4- to 7-membered saturated, monocyclic heterocyclic ring which can optionally be interrupted by an oxygen atom or by the N-CH3 group; R2 can, however, also be linked to A via an alkylene bridge such that, together with the group NR1, a saturated, 5 to 7-membered heterocyclic ring system is formed; R3 is a lower alkyl group, a chlorine atom or a hydrogen atom; R4 is a hydrogen atom or a methyl group; R5 and R6 each denote a hydrogen atom, a fluorine, chlorine or bromine atom or a lower alkyl group; R7 is a hydrogen or chlorine atom or a methyl group; R8 is a hydrogen atom or a lower alkyl radical; R9 is a hydrogen or halogen atom or a lower alkyl group and R10 is a hydrogen atom or a methyl group, where in the case in which IMAGE represents the divalent radical (T) and R7 is hydrogen, R3 cannot be chlorine and Z cannot be sulphur. Processes for their preparation and medicaments which contain these compounds are also described. In view of the lack of gastric acid secretion-inhibiting, salivation-inhibiting and mydriatic influences, the novel diazepinones are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias in human and veterinary medicine.