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Method for preparing ariloxi and ariltio - hidroxipropilen - piperazinil - acetanilides cardioselectivas affecting Calcium entry.
Method for preparing ariloxi and ariltio - hidroxipropilen - piperazinil - acetanilides cardioselectivas affecting Calcium entry.
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机译:制备影响钙进入的阿利洛西和阿利洛西-盐酸吡咯烷酮-哌嗪腈-对乙酰苯胺的方法。
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摘要
Novel compounds of the general formula IMAGE (I) and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form -OCH2O-; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonylmethyl, cyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form -CH=CH-CH=CH-; R7 and R8 together form -OCH2O-; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.
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