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Novel Surfactant material, method for producing the same and remedy for Respiratory stress Syndrome that contain it.
Novel Surfactant material, method for producing the same and remedy for Respiratory stress Syndrome that contain it.
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机译:新型表面活性剂材料,产生该表面活性剂的方法以及包含该表面活性剂的呼吸道压力综合症的治疗方法。
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摘要
A surface active material having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. This material comprises, based on the dry weight of the material, 68.6-90.7% of phospholipid, 0.3-13.0% of neutral fat, 0.0-8.0% of total cholesterol, 1.0-27.7% of free fatty acids, 0.1-2.0% of carbohydrate, and 0.0-3.5% of protein. The material is produced by subjecting mammalian lung tissue to a series of procedures including acetic acid ester treatment, organic solvent mixture treatment, differential centrifugation, density gradient centrifugation and dialysis, and optionally adding a phosphatidylcholine, a neutral fat, and/or a free fatty acid to the resulting product. A pharmaceutical composition comprising the surface active material is usable for the clinical treatment of respiratory distress syndrome.
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