首页> 外国专利> 1-(4-AMINO-3,5-DICHLOORFENYL)-2-(SUBSTITUTED AMINO)-ETHANOL ASSOCIATION WITH ASSOCIATED ADDRESSING AUTHORITIES; PHARMACEUTICAL PREPARATION.

1-(4-AMINO-3,5-DICHLOORFENYL)-2-(SUBSTITUTED AMINO)-ETHANOL ASSOCIATION WITH ASSOCIATED ADDRESSING AUTHORITIES; PHARMACEUTICAL PREPARATION.

机译:1-(4-氨基-3,5-二氯甲苯基)-2-(取代的氨基)-乙醇协会及相关地址处理机构;药物制剂。

摘要

The invention provides compounds of the general formula (I) IMAGE (I) wherein X represents a bond or a C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain, and Y represents a bond, or a C1-4 alkylene, C2-4 alkenylene or C2-4 alkynylene chain with the proviso that the sum total of carbon atoms in X and Y is not more than 8; Py represents a pyridyl group optionally substituted by one or two substituents selected from halogen atoms, hydroxy, C1-3 alkyl and C1-3 alkoxy groups; and R1 and R2 each represent a hydrogen atom or a C1-3 alkyl group, with the proviso that the sum total of carbon atoms in R1 and R2 is not more than 4; and physiologically acceptable salts and solvates (e.g. hydrates) thereof. The compounds have a stimulant action at beta 2-adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
机译:本发明提供了通式(I)的化合物(I),其中X表示键或C 1-6亚烷基,C 2-6亚烯基或C 2-6亚炔基链,且Y表示键或C 1- 4个亚烷基,C2-4亚烯基或C2-4亚炔基链,条件是X和Y中的碳原子总数不超过8; Py代表吡啶基,其任选地被一个或两个选自卤素原子,羟基,C1-3烷基和C1-3烷氧基的取代基取代; R1和R2分别代表氢原子或C1-3烷基,条件是R1和R2中的碳原子总数不超过4。及其生理上可接受的盐和溶剂化物(例如水合物)。该化合物对β2-肾上腺素受体具有刺激作用,可用于治疗与可逆性气道阻塞相关的疾病,例如哮喘和慢性支气管炎。

著录项

  • 公开/公告号NL188408B

    专利类型

  • 公开/公告日1992-01-16

    原文格式PDF

  • 申请/专利权人 GLAXO GROUP LIMITED TE LONDEN GROOT-BRITTANNIE.;

    申请/专利号NL19870000326

  • 发明设计人

    申请日1987-02-11

  • 分类号C07D213/30;A61K31/44;

  • 国家 NL

  • 入库时间 2022-08-22 05:34:57

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