method for preparing a medicine with effects on the central nervous system and method for the preparation of medicinal acetohydroxaminezuurderivaten.

摘要

The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R1R2R3C-CO-NHOH, in which R2 and R3 are each hydrogen or C1-6 alkyl, and R1 is C1-6 alkyl Z1Z2N (where Z1 and Z2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z3CH2- (where Z3=optionally substituted aryl), Z4-A- (where Z4 is optionally substituted phenyl or naphthyl, and A is -NH-, -N(C1-4 alkyl)-, -N(C5-6 cycloalkyl)-, -NHCO-, -N(C1-4 alkyl)CO-, -N(C5-6 cycloalkyl)CO-, -CONH-, -CON(C1-4 alkyl)-, -CON(C5-6 cycloalkyl)-, -NHCONH-, -N(C5H6)CONH-, or -N(substituted phenyl)CONH-, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.