BENZO(B)PYRAZINO(1,2-D)PYRROLO-(3,2,1-JK)(1,4)BENZODIAZEPINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

The present invention relates to 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines of the formula CHEM wherein R is hydrogen, loweralkyl, or a group of the formula COO(CR1Z)mCR2R3R4, wherein R1, R2, R3, and R4 are independently hydrogen or loweralkyl, Z is hydrogen, loweralkyl, or halogen, and m is 0 or 1; X and Y are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; the dotted line represents an optional carbon-tocarbon bond; an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for treating depression alone or in combination with inert adjuvants. The invention relates also to a process and intermediates for the preparation of the above compounds.