PREPARATION PROCESS OF DI-SUBSTITUTED ACETYLENES WITH HETEROAROMATIC AND HETEROBICICLIC GROUPS PRESENTING ACTIVITY OF THE TYPE RETINOIDE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAINS THEM

摘要

Retinoid-like activity is exhibited by compounds of the formula CHEM where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.