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METHOD FOR PREPARING REVERSE GELIFICATION COMPOSITIONS, BASED ON TEMPERATURE SENSITIVE POLYMERES AND PH, FOR EXAMPLE METHYL CELLULOSE AND POLYACRYLATE
METHOD FOR PREPARING REVERSE GELIFICATION COMPOSITIONS, BASED ON TEMPERATURE SENSITIVE POLYMERES AND PH, FOR EXAMPLE METHYL CELLULOSE AND POLYACRYLATE
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机译:基于温度敏感的聚合物和pH值,例如甲基纤维素和聚丙烯酸酯的逆胶凝成分的制备方法
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摘要
Reversibly gelling aqueous compositions are disclosed which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer and at least one temperature-sensitive reversibly gelling polymer. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.
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