PRODUCTION PROCESS OF 1,6 - DI (N3 - CIANO - N1 GUANADINO) HEXANO

摘要

In an improved process for the preparation of 1,6-di(N3-cyano- N1-guanidino)hexane from alkali metal dicyanamide and a hexamethylenediammonium salt in alcoholic solution or suspension, the reaction is carried out in the presence of a limited amount of water and a catalytic amount of a base, preferably a tertiary amine and the pH of the reaction mixture is 8 to 10 at the beginning of the reaction. After the reaction is complete, water is added to the reaction mixture in the heat, above 80 DEG C, and the coarse-crystalline product formed is separated off from the liquid phase. …??Preferably, sodium dicyanamide and hexamethylenediamine dihydrochloride, preferably formed in situ from aqueous 1,6-diaminohexane and aqueous hydrochloric acid, are reacted in n-butanol in the presence of 0.1 to 20% by weight of water, relative to the solvent including water, at a pH of 9-9.5. …??1,6-di(N3-cyano-N1-guanidino)hexane is obtained in a high yield (85-96%) and in high purity (95-97%) and with a substantially increased space-time yield.