MONOCLONAL ANTIBODIES REACTIVE WITH NORMAL AND ONCOGENIC FORMS OF THE RAS P21 PROTEIN

摘要

TITLE NN-O211MONOCLONAL ANTIBODIES REACTIVE WITH NORMAL ANDONCOGENIC FORMS OF THE ras p21 PROTEINABSTRACT OF THE DISCLOSUREMonoclonal antibodies reactive with normal anoncogenic forms of the ras p21 protein. Theantibodies are secreted by hybridomas obtained byimmunizing mice with the Ha ras p21 protein containingthe arginine mutation at position 12 of the protein.The antibodies and immunoreactive fragments thereof ofuseful for detection, diagnosis, quantitation, stagingand classification of normal and activated ras p21s innormal tissues, malignant and premalignant lesions.