USE OF OXAZOLO-2,3-A-ISOINDOLE AND IMIDAZO-2,1-A- ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS, AS WELL AS NEW OXAZOLO-2,3-A-ISOINDOLE DERIVATIVES

摘要

2108899 9216207 PCTABS00016 The invention concerns the use of oxazolo-¢2,3-a!isoindole and iminazo¢2,1-a!isoindole derivatives as antiviral drugs, as well as optically active derivatives, new oxazolo-¢2,3-a!isoindole derivatives, a method for preparing them and drugs containing these compounds. In particular, the subject matter of the invention is the use of oxazolo-¢2,3-a!isoindole and imidazo¢2,1-a!isoindole derivatives of general formula (I) to produce antiviral drugs. In formula (I), X stands for an oxygen atom or a sulphur atom, the imino group =NH or a =N-C1-C5 alkylimino group, Y stands for an oxygen atom or the group NR7, wherein R7 is a hydrogen atom or a C1-C6 alkyl residue or a C1-C6 acyl residue, R is a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphataic residue containing 1-9 carbon atoms, possibly substituted by phenyl, or a phenyl ring possibly substituted one or more times, or a carbocyclic or heterocyclic ring, R1 and R2 stand for a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphatic residue with 1 to 6 carbon atoms, R3-R6 stand for hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylmercapto, amino, C1-C6 alkylamino, di-C1-C6 alkylamino, halogen, cyano, hydroxy, carboxy, aminocarbonyl, substituted aminocarbonyl or C1-C6 alkoxycarbonyl. The invention also concerns their tautomers, enantiomers, diastereomers and physiologically acceptable salts.