1-AMINOALKYL-3-OXYSUBSTITUTED-4-ARYL-1,3,4,5-TETRAHYDRO-2H- 1,3-BENZODIAZEPINE-2-ONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

摘要

This invention relates to 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodi azepine-2- ones having the formula CHEM where R1 and R2 are each independently hydrogen, loweralkyl, aryl, arylloweralkyl or acyl; R3 is hydrogen, loweralkyl, arylloweralkyl aryl or acyl; X is hydrogen, halogen, hydroxy loweralkyl, loweralkoxy, NO2, NH2 or CF3; m is an integer of 1 to 3, n is an integer of 1 to 3; the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometric and optical isomers thereof. The compounds of this invention display utility as analgesics, calcium ion antagonists and antihypertensives, and can, therefore, be used as medicaments.