NOVEL HYDROXAMATE DERIVATIVES OF SELECTED NONSTEROIDAL ANTIINFLAMMATORY ACYL RESIDUES HAVING CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITION

摘要

A compound of the formula CHEM and pharmaceutically acceptable acid addition or base salts thereof wherein i) RCO is an acyl residue of selected NSAIDS; ii) R1 is hydrogen, lower alkyl or acyl; iii) R2 is H, lower alkyl, cycloalkyl of from three to twelve carbon atoms of which from three to seven carbons are ring carbons, aryl, arylalkyl or heteroaryl having cyclooxygenase or 5-lipoxygenase inhibitory activity.