ARYL-AND HETEROARYLETHANOL-PYRIDYLALKYLAMINES, PROCESS FOR THE PREPARATION THEROF AND THE USE THERE OF AS PRODUCTION PROMOTERS IN LIVESTOCK AND AS AGENTS AGAINST OBESITY

摘要

Novel aryl- and heteroarylethanolpyridylalkylamines of the formula I …IMAGE… in which… A stands for =CH- or =N-,… R0 stands for hydrogen or methyl,… R1 stands for hydrogen, hydroxyl, halogen, cyano, alkyl, haloalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, haloalkoxy, haloalkylthio or NHSO2-alkyl,… R2 stands for hydrogen, hydroxyl, alkoxy or the radical -NR5R6,… R3 stands for the radicals given under R1,… R4 stands for hydrogen, C1-C10-alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical -NR7R8, and also for the radical COR9 or the radical -O-Z-R10,… Z stands for C1-C10-alkylene, -alkenylene or alkynylene,… R5 represents hydrogen or alkyl,… R6 represents hydrogen, alkyl, haloalkyl or acyl, where R5 and R6, together with the adjacent N atom, can form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring,… R7 stands for hydrogen, optionally substituted alkyl or optionally substituted aryl,… R8 stands for the radicals indicated under R7,… R9 stands for hydroxyl, alkoxy or the radical -NR7R8,… R10 stands for hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy,… where in the pyridyl ring of the formula I the substituent R4 and the alkylamino group are in the p-position to one another,… and their physiologically tolerable salts and, if A stands for nitrogen, their N-oxides. …??The present invention furthermore relates to processes for the preparation of the compounds, intermediates used in this process, and their use as performance promoters in animals and as anti-obesity agents.