ANTIGENS ASSOCIATED WITH POLYMYOSITIS AND WITH DERMATOMYOSITIS

摘要

Isolated DNA molecules encoding at least one epitope of the Mi-2 antigen and at least one epitope of the PM-Scl antigen are provided. The DNA may be used as probes to obtain related DNA. Proteins expressed from the DNA may be used in assays for the diagnosis of dermatomyositis and polymyositis, particularly polymyositis-scleroderma overlap disorders. The expressed proteins may also be used for purification of the associated autoantigens.