ANTIFUNGAL ACTIVITY OF AND PREVENTION OF DRUG INDUCED NEPHROTOXICITY BY METHYLXANTHINE ANALOGUES

摘要

The present invention involves the usage of certain hemorheological methylxanthine analogs having structure (I) where R1 is -(CH2)4COCH3, or -(CH2)4COH(CH3)2 and R2 is -CH3, -H or CH2OCH2CH3. These methylxanthine analogs may be used for treating a systemic fungal infection, for example candidiasis. Administration of the analogs, preferably by parenteral means, at least once and possibly on a multiple dosage schedule may be used to effectively ameliorate systemic fungal infections. The preferred therapeutically effective dosage for such treatment is between 1 mg and 100 mg per kg animal weight. A preferred analog for this treatment is when R1 is -(CH2)4COH(CH3)2 and R2 is -H. The above analogs may generally be used to treat an animal to inhibit developement of or to alleviate renal dysfunction manifested by reductions in renal blood flow and glomerular filtration rates with increased vascular resistance. This dysfunction may be independent or relate to the toxicity of other drugs such as cyclosporine or amphotericin B.