POLYPEPTIDES HAVING A HUMAN $g(b) ADRENERGIC RECEPTOR ACTIVITY, AND PLAYING A ROLE IN LIPOLYTIC RESPONSE, NUCLEIC ACIDS CODING FOR THESE POLYPEPTIDES AND USE OF SAID POLYPEPTIDES FOR SCREENING SUBSTANCES WHICH ACT ON THESE POLYPEPTIDES

摘要

The invention relates to novel polypeptides having beta-adrenergic receptor activity containing: the sequence of 402 amino acids, or a fragment of this sequence, this fragment being such that either it nevertheless contains in particular the sites contained in this sequence and whose presence is necessary for that, when this fragment is exposed at the surface of a cell, it is capable of participating in the activation of adenylate cyclase in the presence of an agonist, or it is capable of being recognized by antibodies which also recognize the abovementioned sequence of 402 amino acids, but recognize neither the adrenergic receptor beta1 or beta2 adrenergic receptor. These polypeptides are useful for screening drugs active on said polypeptides and for the treatment of obesity, fatty diabetes and hyperlipidaemia.