Process for the preparation of N-formyl-alpha-L-aspartyl-L-phenylalanine methyl ester

摘要

To produce N-formyl- alpha -L-aspartyl-L-phenylalanine methyl ester there is carried out a reaction of N-formyl-L-aspartic acid anhydride with L-phenylalanine methyl ester in a reaction solvent and in the presence of acetic acid and formic acid and in a complete mixing type continuous reaction mode. By this process, the amount of the desired ester produced, relative to its beta -isomer, is increased.