Naphthoquinones for the treatment and prophylaxis of pneumocystis carinii infections

摘要

The present invention relates to the use of known and novel naphthoquinones in the treatment and prophylaxis of Pneumocystis carinii infections, and for the manufacture of medicaments for the treatment and prophylaxis of P.carinii infections, novel formulations containing said compounds, and novel naphthoquinones of formula (VI): whereinR¹¹ and R¹² each represent =O and the dotted line represents a double bond between the 2 and 3 positions of the quinone ring, in which case R¹³ represents a group -OCOR⁵; a group OR⁶ or SR⁶; or a group NR⁷R⁸; or the dotted line represents double bonds at the 1,2 and 3,4 positions of the quinol ring and R¹¹, R¹² and R¹³ each represents a group -OCOR¹⁴, wherein R¹⁴ represents an optionally substituted C₁₋₁₀alkyl group.