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PROCESS FOR PREPARING CONTROLLED RELEASED MICROCAPSULE CONTAINING WATER SOLUBLE DRUGS
PROCESS FOR PREPARING CONTROLLED RELEASED MICROCAPSULE CONTAINING WATER SOLUBLE DRUGS
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机译:制备含水溶性药物的受控释放微胶囊的方法
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摘要
The method for producing a controlled release-type microcapsule is characterized by (a) adding an aqueous soln. of water- soluble drug and diethylene triamine (or tetraethylene pentamine) to an organic soln. of polyvinyl pyrrolidone surfactant and cebacoyl (or terephthaloyl adipoyl, isophthaloyl) chloride, (b) agitating the mixed soln. to obtain a polyamide microcapsule by the interfacial polymerization, (c) coating the capsule with a chloroform soln. contg. C12-18 fatty acid as an organic conating agent, and (d) drying the coated capsule.
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