METHOD FOR SYNTHESIS OF ISOINDOLINONE DERIVATIVES OR THEIR SALTS

摘要

Compounds of formula: IMAGE (I) in which: either R1 represents 4-phenyl-1,2,3,6-tetrahydro-1-pyridyl or 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-pyridyl, R2 represents hydrogen, alkoxy of 1 or 2 carbon atoms, hydroxyl, alkyl, alkylthio, alkylcarbonyloxy, phenylalkylcarbonyloxy, phenylalkyl or -NR4R5 in which R4 represents hydrogen or alkyl and R5 represents alkyl, phenyl, monohalogenated phenyl or pyridyl, and R3 represents a hydrogen atom, or else R2 represent phenyl and R3 represents hydrogen or hydroxyl; or R1 represnets 4-phenyl-1-piperazinyl whose phenyl nucleus has a substituent halogen atom or hydroxyl radical in the 4-position, R2 represents alkoxy and R3 represents hydrogen; it being understood that when R1 represents the 4-phenyl-1,2,3,6-tetrahydro-1-pyridyl radical, R2 is not hydroxyl and that, unless otherwise stated, the alkyl and alkoxy radicals and the alkyl and alkoxy portions contain 1 to 4 carbon atoms each in a straight or branched chain, and addition salts thereof with an inorganic or organic acid, are useful in therapy for their serotonin antagonist properties.