antigestagene for inhibition of uterine prostaglandin synthesis.

摘要

The use of antigestagens (I) for inhibiting uterine prostaglandin synthesis is new. (I) is 11beta-Q-17beta-hydroxy-17alpha-propynyl- 4,9(10)-oestradien-3-one and its 18-methyl analogue; 11beta-Q-17abeta. hydroxy-17a alpha-propynyl- D-homo-4,9(10),16-oestradien- 3-one; 11beta-methoxyphenyl-17betahydroxy- 17alpha-ethynyl-4,9(10) oestradien-3-one; 11-Q-17beta-hydroxy- 17alpha-hydroxyprop-1-(Z)-enyl-4,9(10)-oestradien-3-one and 11-Q-17alpha-hydroxy-17beta-(3-hydroxypropyl) -13alphamethyl-4,9 (10)-gonadien-3-one (Ia). (Q= 4-dimethylaminophenyl).