The instant invention relates to a drug-delivery device for the controlled release of a therapeutically active ingredient into an environment of use which comprises: (A) a core composition comprising (a) a water insoluble, non-diffusible charged resin entity, and (b) a diffusible water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and (B) an imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall; or (C) a water insoluble wall surrounding said core composition and prepared from (i) a polymer material that is permeable to water but substantially impermeable to solute and (ii) 0.1 to 75% by weight, based on the total weight of (i) and (ii), of at least one water leachable pore forming additive dispersed throughout said wall. c
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机译：本发明涉及一种用于将治疗活性成分控制释放到使用环境中的药物输送装置，该装置包括：（A）核心组合物，其包含（a）水不溶，不可扩散的带电树脂实体，和（ b）带有与所述树脂实体相同电荷的可扩散的水溶性可电离的治疗活性成分; （B）围绕所述芯组合物的无孔的水不溶性壁，由在使用环境中基本上不渗透芯组合物并且可渗透外部流体通过的半渗透性材料制成，所述壁具有用于释放治疗剂的装置剂通过水不溶性壁;或（C）围绕所述核心组合物的水不溶性壁，其由（i）可渗透水但基本上不溶质的聚合物材料和（ii）基于（i）总重量的0.1至75重量％制备）和（ii）至少一种分散在整个所述壁上的可水浸出的造孔添加剂。 C
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