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Modified Gram negative bacteria for use as vaccine and adjuvant - are transformed to express lytic protein or toxin, forming ghost(s) which present many cell wall epitope(s)
Modified Gram negative bacteria for use as vaccine and adjuvant - are transformed to express lytic protein or toxin, forming ghost(s) which present many cell wall epitope(s)
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机译:用作疫苗和佐剂的修饰革兰氏阴性细菌被转化以表达裂解蛋白或毒素,形成具有许多细胞壁表位的幽灵
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摘要
Modified bacteria, obtd. by (1) transforming a Gram negative bacterium with (a) the gene of a lytic membrane protein of a bacteriophage, (b) a lytic toxin-release gene or (c) their partial sequences which code for lytic proteins; (2) culturing the bacteria, (3) expressing the lytic genes and (4) isolation from the culture broth, are used as vaccines or adjuvants. - Pref. during culture, activation of the gene is inhibited or expression is repressed, and lifted only at selected times. The lytic gene is the DNA sequence for the E or L proteins (or their membrane-penetrating domains) or the EL-hybrid protein, or their active partial sequences.
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