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METHOD FOR PRODUCING 4'-CHLORINE-2 - ((3- (10,11-DIHYDRO-5H-DIBENZ (B, F) AZEPIN-5-YL) PROPYL) METHYLAMINNO) ACETOPHENONE AND ITS SALTS, THE STABILIZATION OF ITS SALTS, HERBY AVAILABLE PRODUCTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
METHOD FOR PRODUCING 4'-CHLORINE-2 - ((3- (10,11-DIHYDRO-5H-DIBENZ (B, F) AZEPIN-5-YL) PROPYL) METHYLAMINNO) ACETOPHENONE AND ITS SALTS, THE STABILIZATION OF ITS SALTS, HERBY AVAILABLE PRODUCTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
A process is disclosed for the preparation of purified storage stable Lofepramine and/or its salts using Desipramine and 2-bromo-4'-chloroacetophenone in a two-phase system by crystallizing the crude product from methyl-tert-butylether. This product can then be converted by known procedures to its amine salts and can be used for the preparation of pharmaceutical compositions.
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