New 5-amino-4-di:alkoxy:phosphoryl-oxazole derivs. - prepd. by reacting phosphonate salt with amine, are useful as fungicides

摘要

5-amino-4-dialkoxyphosphoryl-oxazole derivs. (I) are new. Where R1, R2 = 1-7C alkyl; and R3 = H or 1-3C alkyl; or NR2R3 = morpholino or piperidino. (I) is prepd. by reacting phosphonate salt of formula with amine of formula HNR1R2. Reaction is opt. in the presence of a base and a solvent at 0-60 deg.C. USE - Cpds. are used as fungicides. In an example, dimethylamine (III) (2.25g) in dichloromethane (10ml) was added to dimethyl 1-formylamino-2,2,2-trichloroethane-phosphonate (II) (2.84g) in dichloromethane (10ml) and the mixt. was stirred, extracted (H20) and dried. Distn. and chromatography gave 5-dimethylamino-4-dimethoxyphosphoryl-oxazole (I) (1.87g; 85%) n25 = 1.5030.