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16-decarboxy-16-hydroxy derivatives of amphotericin B
16-decarboxy-16-hydroxy derivatives of amphotericin B
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机译:两性霉素B的16-去羧基-16-羟基衍生物
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摘要
Compounds of the formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is --CH.sub.2 OH; R.sub.2 is hydrogen or C.sub.1-8 alkyl; R.sub.3 is hydrogen or an amine protection group; and each R.sub.4 is hydrogen; their preparation, compositions containing them and their use in the treatment of fungal infections are described.
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机译:式(I)化合物或其药学上可接受的盐:其中R.sub.1是-CH.sub.2 OH; R 2是氢或C 1-8烷基; R 3是氢或胺保护基;每个R 4是氢;描述了它们的制备,包含它们的组合物及其在治疗真菌感染中的用途。
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