Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety

摘要

Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S→(O).sub.n (n=0 or 2); P PR.sub.1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2- amino-4- thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R.sub.1 is trifluoromethyl, pyridyl-2,pyridyl-4;P PR. sub.2 is H, methoxy, hydroxy; orPPR.sub.1 and R.sub.2 are --CH═CH--CH═CH--;PPR.sub.3 and R. sub.4 are methoxy, hydroxy, fluorine or form a fused benzene ring; PP CR.sub.5 R.sub.6 R.sub.7 is carboxymethyl, --CH.sub.2 --PO. sub.3 H,--CH. sub.2 --PO(oET).sub.2, 4-methylpiperazinyl, aminomethyl,3-4- 5- trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy- carbopnylthiomethyl, --CH--CONH.sub.2, ##STR2## substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R.sub.4 and R.sub.5 form a fused benzene ring on the positions 5 and 6, 6 and 8 or 7 and 8 are disclosed. These compounds possess anticancer activity in particular antipancreatic cancer activity together with immunomodulating activity.