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Asexual blood stage antigens of Plasmodium falciparum which encode a rhoptry protein
Asexual blood stage antigens of Plasmodium falciparum which encode a rhoptry protein
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机译:恶性疟原虫的无性血液阶段抗原,编码一种重组蛋白
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摘要
DNA molecules comprising artificially constructed polynucleotide sequences substantially coresponding to all or a portion of the base sequence coding for an antigen of Plasmodium faliciparum selected from the group consisting of the Acidic Basic Repeat Antigen Rhoptry (ABRA), the antigen of any of clones Ag 169, Ag303, Ag358, Ag361, Ag372, Ag394 or Ag501, defined herein, and other antigens of P. falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the above antigens of P. falciparum. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polyupeptide displaying the antigenicity of the above antigens of P. falciparum, together with a pharmaceutically acceptable carrier therefor.
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