N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents

摘要

Certain N-2,6-dialkyl- or N-2,6-dialkoxphenyl-N'- diarylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis with urea and thiourea compounds.