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Isolation and structural elucidation of the cyclic peptide hymenistatin 1
Isolation and structural elucidation of the cyclic peptide hymenistatin 1
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机译:环肽处女膜抑素1的分离与结构解析
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摘要
A new and demonstratably active cyclo-octapeptide is isolated from the South Pacific Ocean Hymeniacidon sp. and structurally elucidated. The substance, herein denominated Hymenistatin 1, demonstrated utility by inhibiting tumor growth when measured by the National Cancer Institute P388 leukemia cell line (ED.sub.50 =3.5 g/mL). Hymenistatin 1 has the following structure: ##STR1##
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机译:从南太平洋Hymeniacidon sp。分离出一种新的且具有明显活性的环八肽。并在结构上加以说明。当用美国国家癌症研究所P388白血病细胞系(ED.sub.50 = 3.5 g / mL)测量时,该物质在本文中被称为处女膜抑素1,通过抑制肿瘤的生长证明具有实用性。处女膜抑素1具有以下结构:## STR1 ##
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