Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors

摘要

This invention is directed to compounds of the formula IMAGE and pharmaceutically acceptable salts thereof wherein R6 is hydrogen or lower alkyl; each R1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino IMAGE X is O, S or NR5; R2 is OR7 or NR7 R8; each R3 and R4 are independently hydrogen or lower alkyl; R5 R7 and R8 are independently hydrogen or lower alkyl; n is 0-3 and m is 0-6. These compounds are useful for treating glaucoma or assessing corneal function in mammals.