CHINESE HAMSTER OVARY CELL DEFICIENT IN DIHYDRODIHYDROFOLATE REDUCTASE AND PRODUCTION THEREOF

摘要

PURPOSE:To obtain cells (serum nondemanding CHO dhfr- cells) of Chinese hamster ovary deficient in dihydrodihydrofolate reductase multiplicable in passage in a serum-free medium. CONSTITUTION:Cells(serum nondemanding CHO dhfr- cells) of Chinese hamster ovary deficient in dihydrodihydrofolate reductase multiplicable in passage in a serum-free medium obtained by culturing cells of Chinese hamster ovary deficient in dihydrodihydrofolate reductase in a serum-free medium.