NEW MATERIAL:A compound expressed by formula I (R1 is OH, amino, alkoxyl, alkylthio or H; R2 is H or amino) and salt thereof. EXAMPLE:8,2'-Anhydro-8-mercapto-9-beta-D-3'-deoxyarabinofuranosyladenine. USE:An antiretrovirus agent. PREPARATION:A compound expressed by formula II (R1' is alkoxyl, alkylthio, acylamino or H; R2' is H or acylamino; R3 is acyl; X is halogen) is reacted with an introducing agent of an mercapto group to provide a compound expressed by formula III, which is then reacted with an alkali to close the ring at the 8-position of the base part and the 2'-position of the sugar part. The acyl protection group is subsequently removed.
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机译：新材料：由式I表示的化合物（R 1为OH，氨基，烷氧基，烷硫基或H; R 2为H或氨基）及其盐。实施例：8，2'-脱水-8-巯基-9-β-D-3'-呋喃糖基丝氨酸腺嘌呤脱氧。用途：抗逆转录病毒剂。制备：由式II表示的化合物（R 1'是烷氧基，烷硫基，酰基氨基或H; R 2'是H或酰基氨基; R 3是酰基; X是卤素）与引入剂反应巯基基团形成式III所示的化合物，然后使其与碱反应以在碱部分的8位和糖部分的2'位闭环。随后除去酰基保护基。
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