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STABLE ASPIRIN ENTERIC TABLET

机译:稳定的阿司匹林肠溶片

摘要

PURPOSE:To obtain an aspirin enteric table useful as an analgesic and an antipyretic having improved stability by suppressing hydrolysis of aspirin caused by mutual action of aspirin, an enteric film agent and a plasticizer added to the agent. CONSTITUTION:Aspirin is blended with a proper medical additive such as excipient or lubricant, granulated or tabulated to give tablets and a protecting layer consisting only of suger is made between the tablets and an enteric film comprising an enteric film agent such as hydroxypropylmethyl cellulose phthalate or a methyl methacrylate-methyl acrylate copolymer and a plasticizer such as glycerol fatty acid ester, triacetin or citric acid triethyl ester to give an aspirin enteric tablet showing excellent medicinal effects because hydrolysis of aspirin is suppressed even if allowed to stand under a condition at high temperature, e.g. 50 deg.C and aspirin is stably preserved for a long period of time.
机译:目的:通过抑制因阿司匹林的相互作用而引起的阿司匹林水解,获得用作镇痛药和具有改善稳定性的阿司匹林肠溶表,肠溶膜剂和添加到该剂中的增塑剂。组成:阿司匹林与适当的药物添加剂(例如赋形剂或润滑剂)混合,制成颗粒或制成片剂,并在片剂与包含肠溶膜剂(例如羟丙基甲基纤维素邻苯二甲酸酯或甲基丙烯酸甲酯-丙烯酸甲酯共​​聚物和增塑剂(如甘油脂肪酸酯,三醋精或柠檬酸三乙酯)制成的阿司匹林肠溶片具有优异的药用效果,因为即使在高温条件下放置也可抑制阿司匹林的水解,例如50摄氏度,阿司匹林可长期稳定保存。

著录项

  • 公开/公告号JPH04346930A

    专利类型

  • 公开/公告日1992-12-02

    原文格式PDF

  • 申请/专利权人 SUMITOMO PHARMACEUT CO LTD;

    申请/专利号JP19910149630

  • 发明设计人 NOGUCHI TAKESHI;TOYODA YOKO;TODA TATSUYA;

    申请日1991-05-25

  • 分类号A61K9/28;A61K9/36;A61K31/60;A61K47/26;

  • 国家 JP

  • 入库时间 2022-08-22 05:15:59

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