AGENT FOR PREVENTING AND TREATING TUNICA INTIMAL HYPERPLASIA

摘要

PURPOSE: To provide a tunica intimal hyperplasia-preventing and treating agent containing a tetrazolylalkoxydihydrocarbostyryl compound having a cyclic AMP-increasing activity and a platelet agglutination-inhibiting activity as an active ingredient. ;CONSTITUTION: A tunica intimal hyperplasia-preventing and treating agent contains a tetrazolylalkoxydihydrocarbostyryl compound of the formula (R is cycloalkyl; A is lower alkylene; the dotted line is single bond or double bond) {especially preferably 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4- dihydrocarbostyryl marketed as a vasolilating agent in a trade name of cilostazol} as an active ingredient. The compound inhibits the multiplication of vascular smooth muscle cells, has an effect to prevent and treat tunica intimal hyperplasia, and is useful for preventing and treating coronary artery sclerotization, especially the reobturation of coronary artery especially after PTCA or by the vascular self-retaining of stent.;COPYRIGHT: (C)1993,JPO&Japio