DNA fragment; polipeptideo; vaccine; expression vector; microorganism; insect cell, reagent for detecting the presence of antigenos; treatment process or the prevention of HIV infection.Of allergic reaction and infection or condition in a mammal patologica and process for deteccao of antigenos

摘要

Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.