Mixtures of d and 1 2-(6-methoxy-2-naphthyl)propionic acids or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2-naphthyl)propionic acid; a mixture of the salts of d and 1 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine; a salt of d 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine and a pharmaceutical composition containing this salt in a pharmaceutically effective amount.
展开▼
机译:将d和1的2-(6-甲氧基-2-萘基)丙酸或其可溶盐的混合物与NRD-葡糖胺或其盐进行拆分,其中R为具有2-36个碳原子的烷基或具有3-8个碳原子的环烷基得到基本上富含d 2-(6-甲氧基-2-萘基)丙酸的产物; d与1,2-(6-甲氧基-2-萘基)丙酸的盐与N-R-D-葡糖胺的混合物; d 2-(6-甲氧基-2-萘基)丙酸与N-R-D-葡糖胺的盐和含有该盐的药物有效量的药物组合物。
展开▼