首页> 外国专利> METHOD OF SEPARATING (+)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID FROM A MIXTURE OF (+) AND (-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACIDS

METHOD OF SEPARATING (+)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID FROM A MIXTURE OF (+) AND (-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACIDS

机译:从(+)和(-)-2-(6-甲氧基-2-萘基)丙酸混合物中分离(+)-2-(6-甲氧基-2-萘基)丙酸的方法

摘要

Mixtures of d and 1 2-(6-methoxy-2-naphthyl)propionic acids or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2-naphthyl)propionic acid; a mixture of the salts of d and 1 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine; a salt of d 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine and a pharmaceutical composition containing this salt in a pharmaceutically effective amount.
机译:将d和1的2-(6-甲氧基-2-萘基)丙酸或其可溶盐的混合物与NRD-葡糖胺或其盐进行拆分,其中R为具有2-36个碳原子的烷基或具有3-8个碳原子的环烷基得到基本上富含d 2-(6-甲氧基-2-萘基)丙酸的产物; d与1,2-(6-甲氧基-2-萘基)丙酸的盐与N-R-D-葡糖胺的混合物; d 2-(6-甲氧基-2-萘基)丙酸与N-R-D-葡糖胺的盐和含有该盐的药物有效量的药物组合物。

著录项

  • 公开/公告号CZ277725B6

    专利类型

  • 公开/公告日1993-03-17

    原文格式PDF

  • 申请/专利权人 SYNTEX CORPORATION;

    申请/专利号CS19800004774

  • 发明设计人 HOLTON PERCY GEORGE;

    申请日1980-07-03

  • 分类号C07C59/52;C07C229/34;

  • 国家 CZ

  • 入库时间 2022-08-22 05:12:22

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