3-keto-17alpha-mercapto-17beta- (substituted thio) -androstenderivater of use as intermediates in the preparation of 17,17-bis (substituted thio) -3-ketoandrostener as well as process for their preparation

摘要

Described are androstenes having the formula I …CHEM… or the 1,2-dehydro derivatives thereof… wherein R1 is hydrogen and R2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl, or arylalkyl, or R1 is alkanoyl or aroyl and R2 is alkyl;… R3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alklylthio, arylthio, alkanoyl, alkanoyloxy, or halogen;… R4 is carbonyl, beta -hydroxymethylene or beta -acetyloxymethylene;… R5 is hydrogen or halogen; and… R6 is hydrogen, methyl, hydroxy, alkanoyl or halogen. The androstenes of formula I are useful intermediates for the preparation of steroids having antiinflammatory activity.