Analogifremgangsmaade for the preparation of local anti-inflammatory active 17alpha-carbonate-androst-4-en-3-one 17beta-carboxylic acid esters which degrade in vivo to non-toxic metabolites

摘要

Novel anti-inflammatory agents based on a glucocortico-steroid structure having a general formula I IMAGE the groups R1 to R5, and Z being defined; X is O or S. One example is based on the inactive metabolite cortienic acid which is activated by the introduction of non-toxic substituents at positions 17 alpha - and 17 beta -.