首页>
外国专利>
Cyclic triketonforbindelser and trimethylsilyloxybutadienforbindelser and to their use for the preparation of daunomycinonafledede
Cyclic triketonforbindelser and trimethylsilyloxybutadienforbindelser and to their use for the preparation of daunomycinonafledede
展开▼
机译:环三酮甲酰胺和三甲基甲硅烷氧基丁二烯甲酚及其在制备十二指肠龙胆中的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides novel cyclic triketone compounds of the formulae CHEM wherein S is H, alkyl or alkoxy and R* is a group of the formule CHEM wherein R1 is methyl and R2 is an alkyl group containing at least 2 carbon atoms, or R1 is an alkyl group having 1-4 carbon atoms and R2 is an aryl group, a hetero aryl group, a -CH2OR min , a -CH2N @@ group, a -CH2SR sec group or a -CH2CH=CH2 group, wherein R min and R sec are alkyl groups having 1-4 carbon atoms. These compounds can be used for preparing daunomycinone and derivatives thereof. Daunomycinone is used for preparing daunomycin and adriamycin. By introducing chirality at C-1 of ring A in the preparation of said novel compounds by using a novel diene of formula (1) in a Diels-Alder reaction for said preparation, the chirality of C-3 is established in the subsequent reaction with LiC IDENTICAL CSi(CH3)3 in the synthesis of daunomycinone and derivatives thereof. CHEM This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.
展开▼